Abstract
Abstract Copper oxide nanoparticles (CuO NPs) were synthesised using a reduction agent from aqueous pear extract (Pyrus communis L.) CuO NPs were investigated by transmission electron microscopy, scanning electron microscopy, and X-ray diffraction (XRD) analysis. The XRD pattern of CuO NPS exhibited a facecentred cubic structure. Fourier transform infrared spectroscopy exhibited a stretching vibration of CuO at 408.91 cm–1 . The bactericidal activity of CuO NPs showed significant inhibitory activity against pathogenic bacterial strains, which were investigated against the Gramnegative bacterium Acinetobacter baumannii and the Gram-positive bacterium Streptococcus pyogenes. CuO NPs also showed significant cytotoxicity against human colon cancer (HT-29) cells. Overall, this study revealed that pear extract was an effective reducing agent for CuO NPs formation, exhibiting good biological properties.